Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications

 

J. Fang, A. Mehlich, N. Koga, J. Huang, R. Koga, X. Gao, Ch. Hu, Ch. Jin, M. Rief, J. Kast, D. Baker, H. Li (2013)
Forced protein unfolding leads to highly elastic and tough protein hydrogels
Nature Communications 4, 2974, 10.1038 Link:  [download]


E. Pfitzner, C. Wachauf, F. Kilchherr, B. Pelz, W. Shih, M. Rief and H. Dietz (2013)
Rigid DNA beams for high-resolution single-molecule mechanics
Angewandte Chemie International Edition, Vol 52 (2013), 7766 [Download]




Research Areas

Protein Folding
Protein-Protein Interactions
Molecular Motors
Cytoskeletal Mechanics