Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications


M. Jahn, A. Rehn, B. Pelz, B. Hellenkamp, K. Richter, M. Rief, J. Buchner and T. Hugel (2014)
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
PNAS 2014 111 (50) 17881-17886 Link: www.pnas.org/content/111/50/17881.abstract

L. Rognoni, T. Möst, G. Zoldak. M. Rief (2014)
Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin
PNAS Link:  [download]

Research Areas

Protein Folding
Protein-Protein Interactions
Molecular Motors
Cytoskeletal Mechanics